BiquadFilterNode：detune 属性

const audioCtx = new AudioContext();

//set up the different audio nodes we will use for the app
const analyser = audioCtx.createAnalyser();
const distortion = audioCtx.createWaveShaper();
const gainNode = audioCtx.createGain();
const biquadFilter = audioCtx.createBiquadFilter();
const convolver = audioCtx.createConvolver();

// connect the nodes together

source = audioCtx.createMediaStreamSource(stream);
source.connect(analyser);
analyser.connect(distortion);
distortion.connect(biquadFilter);
biquadFilter.connect(convolver);
convolver.connect(gainNode);
gainNode.connect(audioCtx.destination);

// Manipulate the Biquad filter

biquadFilter.type = "lowshelf";
biquadFilter.frequency.value = 1000;
biquadFilter.gain.value = 25;
biquadFilter.detune.value = 100;